Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Electric fields at the active site of an enzyme: direct comparison of experiment with theory.

Science (New York, N.Y.) - 14 Jul 2006

Suydam Ian T, Snow Christopher D, Pande Vijay S, Boxer Steven G

Abstract excerpt

The electric fields produced in folded proteins influence nearly every aspect of protein function. We present a vibrational spectroscopy technique that measures changes in electric field at a specific site of a protein as shifts in frequency (Stark shifts) of a calibrated nitrile vibration. A nitrile-containing inhibitor is used to deliver a unique probe vibration to the active site of human aldose reductase, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldehyde Reductase
Share to Circular Dichroism
Share to Electricity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enzyme Inhibitors

Share to Nitriles

Share to Spectrophotometry, Infrared

Share to Spectrum Analysis

Share to Static Electricity

Source

Identifiers

PMID: 16840693
DOI: 10.1126/science.1127159

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Electric fields at the active site of an enzyme: direct comparison of experiment with theory.PMID 16840693Read ↗

Predicting mutation-induced Stark shifts in the active site of a protein with a polarized force field.Semantic proximity Read ↗

Long-Range Modulations of Electric Fields in Proteins.Semantic proximity Read ↗

A Critical Test of the Electrostatic Contribution to Catalysis with Noncanonical Amino Acids in Ketosteroid Isomerase.Semantic proximity Read ↗

Electric Fields and Enzyme Catalysis.Semantic proximity Read ↗

Catalytic efficiency of dehaloperoxidase A is controlled by electrostatics--application of the vibrational Stark effect to understand enzyme kinetics.Semantic proximity Read ↗

Long- and Short-Range Electrostatic Fields in GFP Mutants: Implications for Spectral Tuning.Semantic proximity Read ↗

Determining the Electrostatic Contributions of GTPase-GEF Complexes on Interfacial Drug Binding Specificity: A Case Study of a Protein-Drug-Protein Complex.Semantic proximity Read ↗

AESOP: A Python Library for Investigating Electrostatics in Protein Interactions.Semantic proximity Read ↗

Local Electric Field Changes during the Photoconversion of the Bathy Phytochrome Agp2.Semantic proximity Read ↗

Microscopic mechanisms that govern the titration response and pKa values of buried residues in staphylococcal nuclease mutants.Semantic proximity Read ↗

Uncovering specific electrostatic interactions in the denatured states of proteins.Semantic proximity Read ↗

Catalytic efficiency of enzymes: a theoretical analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.