Article
Local Electric Field Changes during the Photoconversion of the Bathy Phytochrome Agp2.
Biochemistry - 12 Oct 2021
Kraskov Anastasia, von Sass Johannes, Nguyen Anh Duc, Hoang Tu Oanh, Buhrke David, Katz Sagie, Michael Norbert, Kozuch Jacek, Zebger Ingo, Siebert Friedrich, Scheerer Patrick, Mroginski Maria Andrea, Budisa Nediljko, Hildebrandt Peter
Abstract excerpt
Phytochromes switch between a physiologically inactive and active state via a light-induced reaction cascade, which is initiated by isomerization of the tetrapyrrole chromophore and leads to the functionally relevant secondary structure transition of a protein segment (tongue). Although details of the underlying cause-effect relationships are not known, electrostatic fields are likely to play a crucial role in...
Topics
- Agrobacterium
- Alanine
- Bacterial Proteins
- Binding Sites
- Light
- Molecular Dynamics Simulation
- Mutation
- Nitriles
- Phytochrome
- Protein Conformation