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Article

Investigation of Cyanide Ligand as an Active Site Probe of Human Heme Oxygenase.

Inorganic chemistry - 5 Apr 2021

Chiura Tapiwa, Mak Piotr J

Abstract excerpt

Human heme oxygenase (hHO-1) is a physiologically important enzyme responsible for free heme catabolism. The enzyme's high regiospecificity is controlled by the distal site hydrogen bond network that involves water molecules and the D140 amino acid residue. In this work, we probe the active site environment of the wild-type (WT) hHO-1 and its D140 mutants using resonance Raman (rR) spectroscopy. Cyanide ligands...

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PMID: 33754715
DOI: 10.1021/acs.inorgchem.0c03611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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