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Article

Electric Fields and Enzyme Catalysis.

Annual review of biochemistry - 20 Jun 2017

Fried Stephen D, Boxer Steven G

Abstract excerpt

What happens inside an enzyme's active site to allow slow and difficult chemical reactions to occur so rapidly? This question has occupied biochemists' attention for a long time. Computer models of increasing sophistication have predicted an important role for electrostatic interactions in enzymatic reactions, yet this hypothesis has proved vexingly difficult to test experimentally. Recent experiments utilizing...

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Identifiers

PMID: 28375745
DOI: 10.1146/annurev-biochem-061516-044432
PMCID: PMC5600505

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