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Article

AT-rich sequence elements promote nascent transcript cleavage leading to RNA polymerase II termination.

Nucleic acids research - 1 Feb 2013

White Eleanor, Kamieniarz-Gdula Kinga, Dye Michael J, Proudfoot Nick J

Abstract excerpt

RNA Polymerase II (Pol II) termination is dependent on RNA processing signals as well as specific terminator elements located downstream of the poly(A) site. One of the two major terminator classes described so far is the Co-Transcriptional Cleavage (CoTC) element. We show that homopolymer A/T tr...

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Identifiers

PMID: 23258704
DOI: 10.1093/nar/gks1335
PMCID: PMC3561976

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23258704-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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