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PUMA Promotes Bax Translocation by Both Directly Interacting with Bax and by Competitive Binding to Bcl-X<sub>L</sub> during UV-induced Apoptosis

13 May 2009

Abstract excerpt

Cell apoptosis induced by UV irradiation is a highly complex process in which different molecular signaling pathways are involved. p53 up-regulated modulator of apoptosis (PUMA) has been proposed as an important regulator in UV irradiation-induced apoptosis. However, the molecular mechanism through which PUMA regulates apoptosis, especially how PUMA activates Bcl-2-associated X protein (Bax) in response to UV...

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PMID: 19439449
DOI: 10.1091/mbc.e08-11-1109

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PUMA Promotes Bax Translocation by Both Directly Interacting with Bax and by Competitive Binding to Bcl-X<sub>L</sub> during UV-induced ApoptosisPMID 19439449Read ↗

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Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR elementSemantic proximity Read ↗

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