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Article

MRPL21 promotes HCC proliferation through TP53 mutation-induced apoptotic resistance.

Tissue & cell - 1 Feb 2024

Ma Tao, Huang Ya-Bin, Chen Jing, Zhang Lu, Liu Yan-Hua, Lu Cui-Hua

Abstract excerpt

BACKGROUND AND AIMS: The specific mechanisms underlying the inhibition of hepatocellular carcinoma (HCC) proliferation and metastasis by mitochondrial apoptosis are not yet fully understood. However, it plays a vital role in suppressing HCC's ability to proliferate and spread. The involvement of MRPL21, a member within the family of mitochondrial ribosomal proteins (MRPs), is well-documented in both cellular...

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Share to Apoptosis
Share to Carcinoma, Hepatocellular
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 38181584
DOI: 10.1016/j.tice.2023.102298

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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