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Article

Mortalin-p53 interaction in cancer cells is stress dependent and constitutes a selective target for cancer therapy.

Cell death and differentiation - 1 Jun 2011

Lu W-J, Lee N P, Kaul S C, Lan F, Poon R T P, Wadhwa R, Luk J M

Abstract excerpt

Stress protein mortalin is a multifunctional protein and is highly expressed in cancers. It has been shown to interact with tumor suppressor protein-p53 (both wild and mutant types) and inactivates its transcriptional activation and apoptotic functions in cancer cells. In the present study, we found that, unlike most of the cancer cells, HepG2 hepatoma lacked mortalin-p53 interaction. We demonstrate that the...

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Identifiers

PMID: 21233847
DOI: 10.1038/cdd.2010.177
PMCID: PMC3131943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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