Article
Metabolic alteration in tumorigenesis.
Science China. Life sciences - 1 Dec 2013
Yang Hui, Xiong Yue, Guan KunLiang
Abstract excerpt
Altered metabolism in cancer was first discovered by Otto Warburg early last century. Although the Warburg Effect has been widely used in tumor detection, relatively little progress had been made in mechanistic understanding of cancer metabolism in the subsequent eight decades. Genetic studies have recently identified mutations in human cancer targeting multiple enzymes involved in intermediate metabolism. One...
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