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Article

Aldosterone synthase gene polymorphism and renal histopathologic changes in kidney transplant patients receiving a calcineurin inhibitor.

Journal of the renin-angiotensin-aldosterone system : JRAAS - 1 Sept 2014

Ruiz-Palacios Patricia C, Rodríguez-Castellanos Francisco E, Mancilla-Urrea Eduardo, Avila-Casado María Del Carmen, Inofuentes-Rivero Mónica X, Rodriguez-Illana Francisco, Fragoso José M, Vargas-Alarcón Gilberto

Abstract excerpt

INTRODUCTION: Aldosterone participates in the pathogenesis of calcineurin inhibitor nephrotoxicity (CIN), producing renal vasoconstriction and transforming growth factor beta (TGFß) expression. The objective of this study was to assess aldosterone polymorphisms and relationships to plasma aldosterone levels and the development of renal histological lesions in kidney transplant patients. MATERIAL AND METHODS:...

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PMID: 23257211
DOI: 10.1177/1470320312470579

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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