Article
Impact of aldosterone synthase gene C-344T polymorphism on IgA nephropathy.
Renal failure - 1 Jan 2011
Bantis Christos, Heering Peter J, Siekierka-Harreis Magdalena, Kouri Nicoletta-Maria, Schwandt Christina, Rump Lars-Christan, Ivens Katrin
Abstract excerpt
AIM: In the past years, aldosterone has been identified as an important mediator of renal injury. In this study, we evaluated the influence of C-344T polymorphism of aldosterone synthase gene, associated with serum aldosterone levels and the development of arterial hypertension, on IgA nephropathy (IgAN). METHODS: We studied n = 143 patients with biopsy-proven IgAN followed up for 7.1 ± 6.2 years. Patients were...
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