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Article

Auto-inhibition of the Dbl family protein Tim by an N-terminal helical motif.

The Journal of biological chemistry - 4 May 2007

Yohe Marielle E, Rossman Kent L, Gardner Olivia S, Karnoub Antoine E, Snyder Jason T, Gershburg Svetlana, Graves Lee M, Der Channing J, Sondek John

Abstract excerpt

Dbl-related oncoproteins are guanine nucleotide exchange factors specific for Rho-family GTPases and typically possess tandem Dbl homology (DH) and pleckstrin homology domains that act in concert to catalyze exchange. Because the ability of many Dbl-family proteins to catalyze exchange is constit...

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Source

Identifiers

PMID: 17337446
DOI: 10.1074/jbc.M700185200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17337446-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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