Article
RHOA controls oncogenic B cell receptor signaling in aggressive lymphoma.
Proceedings of the National Academy of Sciences of the United States of America - 3 Feb 2026
Jacobs Ariana N, Jahn Dominique, Beringer Tim, Wolf Sebastian, Krishnan Ramesh K, Engelke Michael, Häupl Björn, Münch Silvia, Dienstbier Niklas, Pape Martine, Bodach Marion, Yu Xin, Serin Nazli, Wurm-Kuczera Rebecca, Zindel Alena, Döbele Carmen, Chapuy Björn, Staudt Louis M, Scheich Sebastian, Oellerich Thomas
Abstract excerpt
Diffuse large B cell lymphoma (DLBCL) is characterized by a variety of specific genetic alterations that impact signaling pathway dependencies and therapeutic outcomes. Among the recurrently mutated genes, we identified RHOA, a member of the small GTPase family, as a selective dependency in DLBCL. Here, we show that RHOA function is essential for the survival of ABC DLBCL cells because it sustains oncogenic B...
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