<i>GRHL1</i>Acts as Tumor Suppressor in Neuroblastoma and Is Negatively Regulated by MYCN and HDAC3

Abstract excerpt

Neuroblastoma is an embryonic solid tumor of neural crest origin and accounts for 11% of all cancer-related deaths in children. Novel therapeutic strategies are therefore urgently required. MYCN oncogene amplification, which occurs in 20% of neuroblastomas, is a hallmark of high risk. Here, we aimed to exploit molecular mechanisms that can be pharmacologically addressed with epigenetically modifying drugs, such...

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