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Article

Chromosomal damage induced by human adenovirus type 12 requires expression of the E1B 55-kilodalton viral protein.

Journal of virology - 1 May 1990

Schramayr S, Caporossi D, Mak I, Jelinek T, Bacchetti S

Abstract excerpt

Infection of human embryonic kidney cells with adenovirus type 12 results in the induction of damage at specific (17q21-22, 1p36, 1q21, and 1q42-43) and random sites in the cellular chromosomes. A previous study by Durnam et al. (D. M. Durnam, P. P. Smith, J. C. Menninger, and J. K. McDougall, Cancer Cells 4:349-354, 1986) indicated that the expression of viral early region 1 (E1) is sufficient for the induction...

Topics

Adenoviruses, Human
Cell Transformation, Viral
Cells, Cultured
Chromatids
Chromosome Aberrations
Chromosomes, Human, Pair 17
DNA Damage
Embryo, Mammalian
Humans
Kidney
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2325204
DOI: 10.1128/JVI.64.5.2090-2095.1990
PMCID: PMC249365

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2325204-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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