Article
The adenovirus E4 17-kilodalton protein complexes with the cellular transcription factor E2F, altering its DNA-binding properties and stimulating E1A-independent accumulation of E2 mRNA.
Journal of virology - 1 May 1990
Marton M J, Baim S B, Ornelles D A, Shenk T
Abstract excerpt
E2F is a cellular DNA-binding factor. Its binding activity is changed within adenovirus-infected cells so that it binds cooperatively to pairs of properly spaced and oriented E2F recognition sites. In the work described in this report, the conversion to cooperative binding was shown to require the adenovirus E4 17-kilodalton (kDa) polypeptide. Mutant viruses carrying alterations within the E4 17-kDa coding region...
Topics
- Adenovirus Early Proteins
- Adenoviruses, Human
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Line
- Chromosome Mapping
- DNA, Viral
- DNA-Binding Proteins
- Gene Expression Regulation, Viral