Analysis of DNA binding by the adenovirus type 5 E1A oncoprotein.

doi:10.1099/0022-1317-83-3-517

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Analysis of DNA binding by the adenovirus type 5 E1A oncoprotein.

The Journal of general virology - 1 Mar 2002

Avvakumov Nikita, Sahbegovic Majdina, Zhang Zhiying, Shuen Michael, Mymryk Joe S

Abstract excerpt

Adenovirus type 5 E1A proteins interact with cellular regulators of transcription to reprogram gene expression in the infected or transformed cell. Although E1A also interacts with DNA directly in vitro, it is not clear how this relates to its function in vivo. The N-terminal conserved regions 1, 2 and 3 and the C-terminal portions of E1A were prepared as purified recombinant proteins and analyses showed that...

Topics

Adenovirus E1A Proteins
Adenoviruses, Human
Binding Sites
Cell Division
Cellulose
Chromatography, Affinity
Chromatography, Ion Exchange
DNA
DNA, Single-Stranded
DNA-Binding Proteins
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Binding

Protein Structure, Tertiary

Recombinant Fusion Proteins

Saccharomyces cerevisiae

Sepharose

Trans-Activators

Source

Open in PubMed

Identifiers

PMID: 11842246
DOI: 10.1099/0022-1317-83-3-517

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of DNA binding by the adenovirus type 5 E1A oncoprotein.PMID 11842246Read ↗

Promoter targeting by adenovirus E1a through interaction with different cellular DNA-binding domainsSemantic proximity Read ↗

Adenovirus E1A activation domain binds the basic repeat in the TATA box transcription factor.Semantic proximity Read ↗

Suppression of mutations in two Saccharomyces cerevisiae genes by the adenovirus E1A protein.Semantic proximity Read ↗

Epigenetic reprogramming by adenovirus e1a.Semantic proximity Read ↗

Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity.Semantic proximity Read ↗

A region in the C‐terminus of adenovirus 2/5 E1a protein is required for association with a cellular phosphoprotein and important for the negative modulation of T24‐ras mediated transformation, tumorigenesis and metastasis.Semantic proximity Read ↗

Definition of adenovirus type 5 functions involved in the induction of chromosomal aberrations in human cells.Semantic proximity Read ↗

Comparative Sequence Analysis of the Largest E1A Proteins of Human and Simian AdenovirusesSemantic proximity Read ↗

Database of mutations within the adenovirus 5 E1A oncogene.Semantic proximity Read ↗

Adenovirus E1A Targets the DREF Nuclear Factor To Regulate Virus Gene Expression, DNA Replication, and GrowthSemantic proximity Read ↗

Conserved region 3 of the adenovirus type 5 DNA-binding protein is important for interaction with single-stranded DNA.Semantic proximity Read ↗

Adenovirus VARNA1 gene B block promoter element sequences required for transcription and for interaction with transcription factors.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.