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Article

High-affinity Dkk1 receptor Kremen1 is internalized by clathrin-mediated endocytosis.

PloS one - 1 Jan 2012

Mishra Sanjay K, Funair Lacey, Cressley Alex, Gittes George K, Burns R Cartland

Abstract excerpt

Kremens are high-affinity receptors for Dickkopf 1 (Dkk1) and regulate the Wnt/β-catenin signaling pathway by down-regulating the low-density lipoprotein receptor-related protein 6 (LRP6). Dkk1 competes with Wnt for binding to LRP6; binding of Dkk1 inhibits canonical signaling through formation of a ternary complex with Kremen. The majority of down-regulated clathrin-mediated endocytic receptors contain short...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23251700
DOI: 10.1371/journal.pone.0052190
PMCID: PMC3522622

Genes

LRP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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