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Article

Mutation of KREMEN1, a modulator of Wnt signaling, is responsible for ectodermal dysplasia including oligodontia in Palestinian families.

European journal of human genetics : EJHG - 1 Oct 2016

Issa Yasmin A, Kamal Lara, Rayyan Amal Abu, Dweik Dima, Pierce Sarah, Lee Ming K, King Mary-Claire, Walsh Tom, Kanaan Moien

Abstract excerpt

Tooth development is controlled by the same processes that regulate formation of other ectodermal structures. Mutations in the genes underlying these processes may cause ectodermal dysplasia, including severe absence of primary or permanent teeth. Four consanguineous Palestinian families presented with oligodontia and hair and skin features of ectodermal dysplasia. Appearance of ectodermal dysplasia was...

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 27049303
DOI: 10.1038/ejhg.2016.29
PMCID: PMC5027678

Genes

KREMEN1
LRP6
EDA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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