Article
The bioenergetic status relates to dopamine neuron loss in familial PD with PINK1 mutations.
PloS one - 1 Jan 2012
Hilker Rüediger, Pilatus Ulrich, Eggers Carsten, Hagenah Johann, Roggendorf Julia, Baudrexel Simon, Klein Johannes C, Neumaier Bernd, Fink Gereon R, Steinmetz Helmuth, Klein Christine, Hattingen Elke
Abstract excerpt
Mutations in the PINK1 gene cause autosomal recessive familial Parkinson's disease (PD). The gene encodes a mitochondrial protein kinase that plays an important role in maintaining mitochondrial function and integrity. However, the pathophysiological link between mutation-related bioenergetic deficits and the degenerative process in dopaminergic neurons remains to be elucidated. We performed phosphorous ((31)P)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.