Article
Brain mitochondrial impairment in early-onset Parkinson's disease with or without PINK1 mutation.
Movement disorders : official journal of the Movement Disorder Society - 1 Mar 2020
Rango Mario, Dossi Gabriele, Squarcina Letizia, Bonifati Cristiana
Abstract excerpt
BACKGROUND: PINK1 mutations are likely to affect mitochondrial function. The objective of this study was to study brain mitochondrial function in patients with early-onset Parkinson's disease, with or without PINK1 mutations. METHODS: We investigated brain intracellular pH, mitochondrial activity, and energetics with functional magnetic resonance spectroscopy in patients with early-onset Parkinson's disease with...
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