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Article

Myeloid cell 5-lipoxygenase activating protein modulates the response to vascular injury.

Circulation research - 1 Feb 2013

Yu Zhou, Ricciotti Emanuela, Miwa Takashi, Liu Shulin, Ihida-Stansbury Kaori, Landesberg Gavin, Jones Peter L, Scalia Rosario, Song Wen-Chao, Assoian Richard K, FitzGerald Garret A

Abstract excerpt

RATIONALE: Human genetics have implicated the 5-lipoxygenase enzyme in the pathogenesis of cardiovascular disease, and an inhibitor of the 5-lipoxygenase activating protein (FLAP) is in clinical development for asthma. OBJECTIVE: Here we determined whether FLAP deletion modifies the response to vascular injury. METHODS AND RESULTS: Vascular remodeling was characterized 4 weeks after femoral arterial injury in...

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Identifiers

PMID: 23250985
DOI: 10.1161/CIRCRESAHA.112.300755
PMCID: PMC3565603

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