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Article

Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension.

Arthritis and rheumatism - 1 Nov 2013

Derrett-Smith Emma C, Dooley Audrey, Gilbane Adrian J, Trinder Sarah L, Khan Korsa, Baliga Reshma, Holmes Alan M, Hobbs Adrian J, Abraham David, Denton Christopher P

Abstract excerpt

OBJECTIVE: To delineate the constitutive pulmonary vascular phenotype of the TβRIIΔk-fib mouse model of scleroderma, and to selectively induce pulmonary endothelial cell injury using vascular endothelial growth factor (VEGF) inhibition to develop a model with features characteristic of pulmonary...

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Source

Identifiers

PMID: 23839959
DOI: 10.1002/art.38078

Genes

PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-23839959-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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