β-Adrenergic Regulation of Cardiac Progenitor Cell Death Versus Survival and Proliferation

Abstract excerpt

RATIONALE: Short-term β-adrenergic stimulation promotes contractility in response to stress but is ultimately detrimental in the failing heart because of accrual of cardiomyocyte death. Endogenous cardiac progenitor cell (CPC) activation may partially offset cardiomyocyte losses, but consequences of long-term β-adrenergic drive on CPC survival and proliferation are unknown. OBJECTIVE: We sought to determine the...

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