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Control of cytokinesis by β-adrenergic receptors indicates an approach for regulating cardiomyocyte endowment

9 Oct 2019

Abstract excerpt

One million patients with congenital heart disease (CHD) live in the United States. They have a lifelong risk of developing heart failure. Current concepts do not sufficiently address mechanisms of heart failure development specifically for these patients. Here, analysis of heart tissue from an infant with tetralogy of Fallot with pulmonary stenosis (ToF/PS) labeled with isotope-tagged thymidine demonstrated that...

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PMID: 31597755
DOI: 10.1126/scitranslmed.aaw6419

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