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Article

Beta2-adrenergic signaling affects the phenotype of human cardiac progenitor cells through EMT modulation.

Pharmacological research - 1 Jan 2018

Pagano Francesca, Angelini Francesco, Siciliano Camilla, Tasciotti Julia, Mangino Giorgio, De Falco Elena, Carnevale Roberto, Sciarretta Sebastiano, Frati Giacomo, Chimenti Isotta

Abstract excerpt

Human cardiac progenitor cells (CPCs) offer great promises to cardiac cell therapy for heart failure. Many in vivo studies have shown their therapeutic benefits, paving the way for clinical translation. The 3D model of cardiospheres (CSs) represents a unique niche-like in vitro microenvironment, which includes CPCs and supporting cells. CSs have been shown to form through a process mediated by...

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Identifiers

PMID: 28099883
DOI: 10.1016/j.phrs.2017.01.016

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