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Article

Epigenetic inheritance of a cocaine-resistance phenotype.

Nature neuroscience - 1 Jan 2013

Vassoler Fair M, White Samantha L, Schmidt Heath D, Sadri-Vakili Ghazaleh, Pierce R Christopher

Abstract excerpt

We delineated a heritable phenotype resulting from the self-administration of cocaine in rats. We observed delayed acquisition and reduced maintenance of cocaine self-administration in male, but not female, offspring of sires that self-administered cocaine. Brain-derived neurotrophic factor (Bdnf) mRNA and BDNF protein were increased in the medial prefrontal cortex (mPFC), and there was an increased association...

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Identifiers

PMID: 23242310
DOI: 10.1038/nn.3280
PMCID: PMC3531046

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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