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Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function

27 Jun 2018

Abstract excerpt

Addictions are highly heritable disorders, with heritability estimates ranging from 39% to 72%. Multiple studies suggest a link between paternal drug abuse and addiction in their children. However, patterns of inheritance cannot be explained purely by Mendelian genetic mechanisms. Exposure to drugs of abuse results in epigenetic changes that may be passed on through the germline. This mechanism of epigenetic...

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PMID: 29949212
DOI: 10.1111/ejn.14060

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