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Article

PDGFRA gain in low-grade diffuse gliomas.

Journal of neuropathology and experimental neurology - 1 Jan 2013

Motomura Kazuya, Mittelbronn Michel, Paulus Werner, Brokinkel Benjamin, Keyvani Kathy, Sure Ulrich, Wrede Karsten, Nakazato Yoichi, Tanaka Yuko, Nonoguchi Naosuke, Pierscianek Daniela, Kim Young-Ho, Mariani Luigi, Vital Anne, Perry Arie, Ohgaki Hiroko

Abstract excerpt

Glioblastomas with a proneural expression signature are characterized by frequent IDH1 mutations (i.e. genetic hallmarks of secondary glioblastomas) and PDGFRA (platelet-derived growth factor receptor-α) amplification. Mutations in IDH1/2 are frequent and early genetic events in diffuse astrocytomas (World Health Organization grade II), precursor to secondary glioblastomas, but little is known about the role and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23242283
DOI: 10.1097/NEN.0b013e31827c4b5b

Genes

PDGFRA
IDH1
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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