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Article

Autonomous and self-sustained circadian oscillators displayed in human islet cells

14 Dec 2012

Abstract excerpt

AIMS/HYPOTHESIS: Following on from the emerging importance of the pancreas circadian clock on islet function and the development of type 2 diabetes in rodent models, we aimed to examine circadian gene expression in human islets. The oscillator properties were assessed in intact islets as well as in beta cells. METHODS: We established a system for long-term bioluminescence recording in cultured human islets,...

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PMID: 23242133
DOI: 10.1007/s00125-012-2779-7

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