Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus.

doi:10.1136/annrheumdis-2011-200385

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Article

Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus.

Annals of the rheumatic diseases - 1 May 2012

Hughes Travis, Adler Adam, Merrill Joan T, Kelly Jennifer A, Kaufman Kenneth M, Williams Adrienne, Langefeld Carl D, Gilkeson Gary S, Sanchez Elena, Martin Javier, Boackle Susan A, Stevens Anne M, Alarcón Graciela S, Niewold Timothy B, Brown Elizabeth E, Kimberly Robert P, Edberg Jeffrey C, Ramsey-Goldman Rosalind, Petri Michelle, Reveille John D, Criswell Lindsey A, Vilá Luis M, Jacob Chaim O, Gaffney Patrick M, Moser Kathy L, Vyse Timothy J, Alarcón-Riquelme Marta E, James Judith A, Tsao Betty P, Scofield R Hal, Harley John B, Richardson Bruce C, Sawalha Amr H

Abstract excerpt

OBJECTIVES: Systemic lupus erythematosus (SLE) is a sexually dimorphic autoimmune disease which is more common in women, but affected men often experience a more severe disease. The genetic basis of sexual dimorphism in SLE is not clearly defined. A study was undertaken to examine sex-specific genetic effects among SLE susceptibility loci. METHODS: A total of 18 autosomal genetic susceptibility loci for SLE were...

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PMID: 22110124
DOI: 10.1136/annrheumdis-2011-200385
PMCID: PMC3324666

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