Article
G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease.
Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2012
Kwon Michelle, Pavlov Tengis S, Nozu Kandai, Rasmussen Shauna A, Ilatovskaya Daria V, Lerch-Gaggl Alexandra, North Lauren M, Kim Hyunho, Qian Feng, Sweeney William E, Avner Ellis D, Blumer Joe B, Staruschenko Alexander, Park Frank
Abstract excerpt
Polycystic kidney diseases are the most common genetic diseases that affect the kidney. There remains a paucity of information regarding mechanisms by which G proteins are regulated in the context of polycystic kidney disease to promote abnormal epithelial cell expansion and cystogenesis. In this study, we describe a functional role for the accessory protein, G-protein signaling modulator 1 (GPSM1), also known as...
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