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Article

Small changes in enzyme function can lead to surprisingly large fitness effects during adaptive evolution of antibiotic resistance.

Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2012

Walkiewicz Katarzyna, Benitez Cardenas Andres S, Sun Christine, Bacorn Colin, Saxer Gerda, Shamoo Yousif

Abstract excerpt

In principle, evolutionary outcomes could be largely predicted if all of the relevant physicochemical variants of a particular protein function under selection were known and integrated into an appropriate physiological model. We have tested this principle by generating a family of variants of the tetracycline resistance protein TetX2 and identified the physicochemical properties most correlated with organismal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23236139
DOI: 10.1073/pnas.1209335110
PMCID: PMC3535585

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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