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Article

Mammalian prions: tolerance to sequence changes-how far?

Prion - 1 Jan 2000

Salamat Muhammad Khalid, Munoz-Montesino Carola, Moudjou Mohammed, Rezaei Human, Laude Hubert, Béringue Vincent, Dron Michel

Abstract excerpt

Upon prion infection, abnormal prion protein (PrP (Sc) ) self-perpetuate by conformational conversion of α-helix-rich PrP (C) into β sheet enriched form, leading to formation and deposition of PrP (Sc) aggregates in affected brains. However the process remains poorly understood at the molecular level and the regions of PrP critical for conversion are still debated. Minimal amino acid substitutions can impair...

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Identifiers

PMID: 23232499
DOI: 10.4161/pri.23110
PMCID: PMC3609119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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