Article
Polymorphism of the prion protein in mammals: a phylogenetic approach.
Recent patents on DNA & gene sequences - 1 Jan 2009
Martin Renaud, Gallet Paul-François, Rocha Dominique, Petit Daniel
Abstract excerpt
PrP, the principal factor modulating resistance/susceptibility to transmissible spongiform encephalopathies, is a well conserved protein bearing strong phylogenetic information, in spite of its relatively short sequence. The construction of the PrP tree allows inferring the probable ancestral sequence for Bovidae where variants were recorded. This ancestral PrP sequence is constituted by a series of 5...
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