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Article

[Alpha-helix retention in prion proteins].

Genetika - 1 Feb 1998

Kuznetsov I B, Morozov P S, Matushkin Iu G

Abstract excerpt

Prion diseases belong to a group of neurodegenerative disorders caused by conformational changes--destroying the alpha-helices--in prion proteins (PrP). We performed a phylogenetic analysis of 32 PrP sequences and restored the most probable evolutionary spectrum of amino acid substitutions. Although prion proteins are not too conserved judging from the evolutionary rates, conserved substitutions leading only to...

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PMID: 9589849

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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