[Alpha-helix retention in prion proteins].

Article

[Alpha-helix retention in prion proteins].

Genetika - 1 Feb 1998

Kuznetsov I B, Morozov P S, Matushkin Iu G

Abstract excerpt

Prion diseases belong to a group of neurodegenerative disorders caused by conformational changes--destroying the alpha-helices--in prion proteins (PrP). We performed a phylogenetic analysis of 32 PrP sequences and restored the most probable evolutionary spectrum of amino acid substitutions. Altho...

Topics

Amino Acid Substitution
Chemical Phenomena
Chemistry, Physical
Conserved Sequence
Evolution, Molecular
Humans
Mutation
Phylogeny
Prions
Protein Structure, Secondary

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.