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Article

N-terminal helix-cap in α-helix 2 modulates β-state misfolding in rabbit and hamster prion proteins.

PloS one - 1 Jan 2013

Sweeting Braden, Brown Eric, Khan M Qasim, Chakrabartty Avijit, Pai Emil F

Abstract excerpt

Susceptibility of a particular species to prion disease is affected by small differences in the sequence of PrP and correlates with the propensity of its PrP to assume the β-state. A helix-cap motif in the β2-α2-loop of native α-helical rabbit PrP, a resistant species, contains sequence differences that influence intra- and interspecies transmission. To determine the effect the helix-cap motif on β-state...

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Identifiers

PMID: 23675452
DOI: 10.1371/journal.pone.0063047
PMCID: PMC3651167

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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