Article
A structural overview of the vertebrate prion proteins.
Prion - 1 Jan 2000
Pastore Annalisa, Zagari Adriana
Abstract excerpt
Among the diseases caused by protein misfolding is the family associated with the prion protein (PrP). This is a small extracellular membrane-anchored molecule of yet unknown function. Understanding how PrP folds both into its cellular and pathological forms is thought to be crucial for explaining protein misfolding in general and the specific role of PrP in disease. Since the first structure determination, an...
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