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The role of Hv1 and CatSper channels in sperm activation

3 Aug 2010

Abstract excerpt

Elevations of sperm intracellular pH and Ca(2+) regulate sperm motility, chemotaxis, capacitation and the acrosome reaction, and play a vital role in the ability of the sperm cell to reach and fertilise the egg. In human spermatozoa, the flagellar voltage-gated proton channel Hv1 is the main H(+) extrusion pathway that controls sperm intracellular pH, and the pH-dependent flagellar Ca²(+) channel CatSper is the...

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Identifiers

PMID: 20679352
DOI: 10.1113/jphysiol.2010.194142

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