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Article

The ENU-induced cetus mutation reveals an essential role of the DNA helicase DDX11 for mesoderm development during early mouse embryogenesis.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Aug 2012

Cota Christina D, García-García María J

Abstract excerpt

BACKGROUND: DDX11 is a DNA helicase of the conserved FANCJ/RAD3/XPD family involved in maintaining genome stability. Studies in yeast and humans have shown requirements for DDX11 in sister chromatid cohesion and DNA repair. In mouse, loss of Ddx11 results in embryonic lethality. However, the developmental defects of Ddx11 mutants are poorly understood. RESULTS: We describe the characterization and positional...

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Identifiers

PMID: 22678773
DOI: 10.1002/dvdy.23810

Genes

DDX11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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