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Article

The influence of the genetic and non-genetic factors on bone mineral density and osteoporotic fractures in Chinese women.

Endocrine - 1 Feb 2013

Deng Yan-Hua, Zhao Lin, Zhang Min-Jia, Pan Chun-Ming, Zhao Shuang-Xia, Zhao Hong-Yan, Sun Li-Hao, Tao Bei, Song Huai-Dong, Wang Wei-Qing, Ning Guang, Liu Jian-Min

Abstract excerpt

To investigate the effects of genetic and non-genetic factors on bone mineral densities (BMDs) and osteoporotic fractures. This was a cross-sectional study to investigate the relationships between 18 SNPs and non-genetic factors with BMDs and osteoporotic fractures in 1012 Chinese Han women. Five SNPs in genes GPR177, CTNNB1, MEF2C, SOX6, and TNFRSF11B were associated with L1-4 or total hip BMDs. rs11898505 in...

Topics

Accidental Falls
Adult
Aged
Aging
Asian People
Bone Density
China
Cohort Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Cross-Sectional Studies

Female

Genetic Association Studies

Hip Joint

Humans

Lumbar Vertebrae

MADS Domain Proteins

MEF2 Transcription Factors

Middle Aged

Myogenic Regulatory Factors

Source

Identifiers

PMID: 22798246
DOI: 10.1007/s12020-012-9726-8

Genes

CTNNB1
SOX6
SPTBN1

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