Article
Associations between methotrexate treatment and methylenetetrahydrofolate reductase gene polymorphisms with incident fractures in Japanese female rheumatoid arthritis patients.
Journal of bone and mineral metabolism - 1 Jan 2009
Urano Wako, Furuya Takefumi, Inoue Eisuke, Taniguchi Atsuo, Urano Tomohiko, Kotake Shigeru, Sekita Chieko, Inoue Satoshi, Hara Masako, Momohara Shigeki, Kamatani Naoyuki, Yamanaka Hisashi
Abstract excerpt
Several case reports have described associations between pathological nonvertebral fractures and low-dose methotrexate (MTX) in rheumatoid arthritis (RA) patients. Furthermore, a significant association between the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene and incident fractures has been reported in postmenopausal women. We attempted to determine whether MTX use and MTHFR...
Topics
- Aged
- Arthritis, Rheumatoid
- Asian People
- Female
- Fractures, Bone
- Genetic Predisposition to Disease
- Humans
- Methotrexate
- Methylenetetrahydrofolate Reductase (NADPH2)