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DnaN clamp zones provide a platform for spatiotemporal coupling of mismatch detection to DNA replication

11 Dec 2012

Abstract excerpt

Mismatch repair (MMR) increases the fidelity of DNA replication by identifying and correcting replication errors. Processivity clamps are vital components of DNA replication and MMR, yet the mechanism and extent to which they participate in MMR remains unclear. We investigated the role of the Bacillus subtilis processivity clamp DnaN, and found that it serves as a platform for mismatch detection and coupling of...

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PMID: 23228104
DOI: 10.1111/mmi.12115

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