Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data.

doi:10.1093/carcin/bgu010

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Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data.

Carcinogenesis - 1 May 2014

Tang Hongwei, Wei Peng, Duell Eric J, Risch Harvey A, Olson Sara H, Bueno-de-Mesquita H Bas, Gallinger Steven, Holly Elizabeth A, Petersen Gloria, Bracci Paige M, McWilliams Robert R, Jenab Mazda, Riboli Elio, Tjønneland Anne, Boutron-Ruault Marie Christine, Kaaks Rudolph, Trichopoulos Dimitrios, Panico Salvatore, Sund Malin, Peeters Petra H M, Khaw Kay-Tee, Amos Christopher I, Li Donghui

Abstract excerpt

Cigarette smoking is the best established modifiable risk factor for pancreatic cancer. Genetic factors that underlie smoking-related pancreatic cancer have previously not been examined at the genome-wide level. Taking advantage of the existing Genome-wide association study (GWAS) genotype and risk factor data from the Pancreatic Cancer Case Control Consortium, we conducted a discovery study in 2028 cases and...

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Identifiers

PMID: 24419231
DOI: 10.1093/carcin/bgu010
PMCID: PMC4004205

Genes

ATXN2
CLSTN1
CTRB1
EVC
EXO1
FAT2
KCNIP4
MTHFSD
PSG2
ZBED2

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Source receipt: pubmed, retrieved 5 Sept 2026.

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