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Article

JNK pathway activation is controlled by Tao/TAOK3 to modulate ethanol sensitivity.

PloS one - 1 Jan 2012

Kapfhamer David, King Ian, Zou Mimi E, Lim Jana P, Heberlein Ulrike, Wolf Fred W

Abstract excerpt

Neuronal signal transduction by the JNK MAP kinase pathway is altered by a broad array of stimuli including exposure to the widely abused drug ethanol, but the behavioral relevance and the regulation of JNK signaling is unclear. Here we demonstrate that JNK signaling functions downstream of the Sterile20 kinase family gene tao/Taok3 to regulate the behavioral effects of acute ethanol exposure in both the fruit...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23227189
DOI: 10.1371/journal.pone.0050594
PMCID: PMC3515618

Genes

TAOK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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