Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

GDF5 regulates TGFß-dependent angiogenesis in breast carcinoma MCF-7 cells: in vitro and in vivo control by anti-TGFß peptides.

PloS one - 1 Jan 2012

Margheri Francesca, Schiavone Nicola, Papucci Laura, Magnelli Lucia, Serratì Simona, Chillà Anastasia, Laurenzana Anna, Bianchini Francesca, Calorini Lido, Torre Eugenio, Dotor Javier, Feijoo Esperanza, Fibbi Gabriella, Del Rosso Mario

Abstract excerpt

BACKGROUND: TGFß overproduction in cancer cells is one of the main characteristics of late tumor progression being implicated in metastasis, tumor growth, angiogenesis and immune response. We investigated the therapeutic efficacy of anti-TGFß peptides in the control of angiogenesis elicited by co...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to Culture Media, Conditioned

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelial Cells

Share to Epithelial-Mesenchymal Transition

Share to Growth Differentiation Factor 5

Share to Neovascularization, Pathologic

Share to Receptors, Urokinase Plasminogen Activator

Share to Smad Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 23226264
DOI: 10.1371/journal.pone.0050342
PMCID: PMC3511424

Genes

GDF5
SMAD1
SMAD4
SMAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-23226264-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

GDF5 regulates TGFß-dependent angiogenesis in breast carcinoma MCF-7 cells: in vitro and in vivo control by anti-TGFß peptides.PMID 23226264Read ↗

Differential regulation of TGF-β–induced, ALK-5–mediated VEGF release by SMAD2/3 versus SMAD1/5/8 signaling in glioblastomaSemantic proximity Read ↗

Transcriptional responses to direct and indirect TGFβ1 stimulation in cancerous and noncancerous mammary epithelial cells.Semantic proximity Read ↗

LRG1 promotes angiogenesis by modulating endothelial TGF-β signallingSemantic proximity Read ↗

TGF Beta Inhibition for Cancer TherapySemantic proximity Read ↗

Controlling angiogenesis by two unique TGF-β type I receptor signaling pathways.Semantic proximity Read ↗

Tumor Endothelial Cells with Distinct Patterns of TGFβ-Driven Endothelial-to-Mesenchymal TransitionSemantic proximity Read ↗

Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesisSemantic proximity Read ↗

Pro-adhesive phenotype of normal endothelial cells responding to metastatic breast cancer cell conditioned medium is linked to NFκB-mediated transcriptomic regulation.Semantic proximity Read ↗

Angiogenesis: A Target for Cancer TherapySemantic proximity Read ↗

Transforming Growth Factor-beta Regulation of Ephrin Type-A Receptor 4 Signaling in Breast Cancer Cellular Migration.Semantic proximity Read ↗

Tumor angiogenesis is enforced by autocrine regulation of high-mobility group box 1.Semantic proximity Read ↗

Wnt5a is required for proper mammary gland development and TGF-β-mediated inhibition of ductal growthSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.