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Article

Wnt5a is required for proper mammary gland development and TGF-β-mediated inhibition of ductal growth

26 Sept 2007

Abstract excerpt

Transforming growth factor-beta (TGF-beta) plays an essential role in growth and patterning of the mammary gland, and alterations in its signaling have been shown to illicit biphasic effects on tumor progression and metastasis. We demonstrate in mice that TGF-beta (Tgfbeta) regulates the expression of a non-canonical signaling member of the wingless-related protein family, Wnt5a. Loss of Wnt5a expression has been...

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PMID: 17898001
DOI: 10.1242/dev.008250

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