Article
Tumor angiogenesis is enforced by autocrine regulation of high-mobility group box 1.
Oncogene - 17 Jan 2013
van Beijnum J R, Nowak-Sliwinska P, van den Boezem E, Hautvast P, Buurman W A, Griffioen A W
Abstract excerpt
The endothelium plays a pivotal role in the progression of solid tumors and is considered a highly relevant target for therapy. However, it emerges that current clinical angiogenesis inhibitors that act through inhibition of tumor-derived growth factors are prone to inducing drug resistance. Therefore, markers of tumor endothelial cells (ECs) themselves provide attractive novel therapeutic targets. In a screen...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.