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Genetic and epigenetic factors which modulate differentiation propensity in human pluripotent stem cells

22 Dec 2017

Abstract excerpt

BACKGROUND: Human pluripotent stem cell (hPSC) lines are known to have a bias in their differentiation. This gives individual cell lines a propensity to preferentially differentiate towards one germ layer or cell type over others. Chromosomal aberrations, mitochondrial mutations, genetic diversity and epigenetic variance are the main drivers of this phenomenon, and can lead to a wide range of phenotypes....

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PMID: 29377992
DOI: 10.1093/humupd/dmx042

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