Article
Cytotoxic effector function of CD4-independent, CD8(+) T cells is mediated by TNF-α/TNFR.
Transplantation - 15 Dec 2012
Zimmerer Jason M, Horne Phillip H, Fiessinger Lori A, Fisher Mason G, Pham Thomas A, Saklayen Samiya L, Bumgardner Ginny L
Abstract excerpt
BACKGROUND: Liver parenchymal cell allografts initiate both CD4-dependent and CD4-independent, CD8(+) T cell-mediated acute rejection pathways. The magnitude of allospecific CD8(+) T cell in vivo cytotoxic effector function is maximal when primed in the presence of CD4(+) T cells. The current studies were conducted to determine if and how CD4(+) T cells might influence cytotoxic effector mechanisms. METHODS: Mice...
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